Aleksandra Klisic1 ,2, Jovana Moracanin1, Suzana Stijepovic1
1Primary Health Care Center, Podgorica, Montenegro
2University of Montenegro, Faculty of Medicine, Podgorica, Montenegro
Background and Aim: Studies in adults have reported an increased immune-inflammatory parameters in relation to cardiovascular risk. However, no such data are reported in young population. Therefore, the aim of the study was to explore the potential relationship between white blood cells (WBC) and their subsets in relation to cardiovascular risk score (CVRS) in adolescents.
Methods: A cohort of 156 adolescents was included. Biochemical parameters were measured. CVRS was calculated by summarizing several risk factors (i.e., fasting glycaemia, low high density lipoprotein cholesterol (HDL-c), high non-HDL-c, female sex, blood pressure and smoking).
Results: WBC and their subsets except for basophil count were higher in moderate/higher CV risk participants as compared to low CVRS counterparts. Multivariate binary logistic regression analysis showed that WBC [Adjusted OR (95% CI)=1.623 (1.234-2.134); p=0.001], neutrophil count [Adjusted OR (95% CI)=1.486 (1.045-2.113); p=0.027] and eosinophil count [Adjusted OR (95% CI)=1.556 (1.109-2.184); p=0.010] were independently correlated with CVRS.
Conclusion: The associations of WBC, neutrophils and eosinophils and cardiovascular risk in the young population may point out the different mechanisms that lead to CV disease in the adult period.